Using high-speed atomic force microscopy and biochemical assays, we visualized G2L4 reverse transcriptase-mediated DNA repair through microhomology-mediated end joining, including DNA intermediates and ligase activity.
@article{zhang2026g2l4,title={Real-Time Visualization of G2L4 Reverse Transcriptase in DNA Repair via Microhomology-Mediated End Joining},author={Zhang, Pangmiaomiao and Guo, Mo and Zhang, Y. Jessie and Lambowitz, Alan M. and Lin, Yi-Chih},journal={Nature Communications},year={2026},note={Accepted manuscript; preprint posted on bioRxiv in March 2026},}
2022
Anal. Chem.
Cross-Reactive Fluorescent Sensor Array for Discrimination of Amyloid Beta Aggregates
Prepared different aggregation states of amyloid beta peptide and characterized them using transmission electron microscopy (TEM) and CD spectrometer. Discriminated different aggregation states using fluorescence sensor array containing conjugated polyelectrolytes and small molecules, analyzed by PCA and LDA algorithms.
@article{zhang2022fluorescence,title={Cross-Reactive Fluorescent Sensor Array for Discrimination of Amyloid Beta Aggregates},author={Zhang, Pangmiaomiao and Tan, Chunyan},journal={Analytical Chemistry},volume={94},number={14},pages={5469--5473},year={2022},publisher={American Chemical Society},}
2020
ACS ABM
Fluorescence Sensor Array for Discrimination of Urine Proteins and Differentiation Diagnosis of Urinary System Diseases
Yishun Shen, Yuanfang Huang, Pangmiaomiao Zhang, and 4 more authors
Constructed three-unit fluorescence sensor array and realized discrimination of six common urine proteins, their different concentrations and their complex mixtures. Distinguished protein profiles of urine samples from healthy people and patients with different urinary system diseases.
@article{shen2020fluorescence,title={Fluorescence Sensor Array for Discrimination of Urine Proteins and Differentiation Diagnosis of Urinary System Diseases},author={Shen, Yishun and Huang, Yuanfang and Zhang, Pangmiaomiao and Guo, Baochun and Jiang, Hongtao and Tan, Chunyan and Jiang, Yuyang},journal={ACS Applied Bio Materials},volume={3},number={9},pages={5639--5643},year={2020},publisher={American Chemical Society},}
2019
Asian J. Org. Chem.
Phosphine Catalyzed Enantioselective [1+4]-Annulation of Morita-Baylis-Hillman Carbonates with α,β-Unsaturated Imines
Chenxiao Qian, Pangmiaomiao Zhang, Wenjun Li, and 1 more author
Established an organic methodology using phosphine catalyst for [4+1] cycloaddition of unsaturated imine and MBH ester with a wide range of substituent groups to obtain chiral 2-pyrrolines with high yields and good enantioselectivities.
@article{qian2019phosphine,title={Phosphine Catalyzed Enantioselective [1+4]-Annulation of Morita-Baylis-Hillman Carbonates with {$\alpha$},{$\beta$}-Unsaturated Imines},author={Qian, Chenxiao and Zhang, Pangmiaomiao and Li, Wenjun and Li, Pengfei},journal={Asian Journal of Organic Chemistry},volume={8},number={2},pages={242--245},year={2019},publisher={Wiley},}
2017
ChemistrySelect
A Catalyst-Free Cycloaddition Reaction: Access to Spiro[chroman-3,2’-indene-1’,3’-dione] Scaffolds
Yuzhe Han, Yingzu Zhu, Pangmiaomiao Zhang, and 2 more authors
Constructed a facile [3+2] cycloaddition reaction to obtain spiro[chroman-3,2’-indene-1’,3’-dione] incorporating two biologically active scaffolds without need of catalysts and complex operation. Products with high yields were obtained and characterized by NMR, HPLC and X-ray crystallography.
@article{han2017catalyst,title={A Catalyst-Free Cycloaddition Reaction: Access to Spiro[chroman-3,2'-indene-1',3'-dione] Scaffolds},author={Han, Yuzhe and Zhu, Yingzu and Zhang, Pangmiaomiao and Li, Wenjun and Li, Pengfei},journal={ChemistrySelect},volume={2},number={35},pages={11380--11383},year={2017},publisher={Wiley},}
