Catalyst-Free Cycloaddition for Spiro Scaffolds
Facile synthesis of biologically active spiro compounds (Mar 2017 – Oct 2017)
| Advisor: Prof. Pengfei Li | Published: ChemistrySelect 2017 |
Developed a catalyst-free [3+2] cycloaddition reaction to access spiro[chroman-3,2’-indene-1’,3’-dione] scaffolds incorporating two biologically active moieties.
Key Contributions
- Constructed a facile [3+2] cycloaddition reaction to obtain spiro[chroman-3,2’-indene-1’,3’-dione] which incorporates two biologically active scaffolds
- Achieved high yields without the need for catalysts or complex operations
- Characterized products by NMR, HPLC, and X-ray crystallography
Publication
- Han, Y.; Zhu, Y.; Zhang, P.; Li, W.; Li, P. A Catalyst-Free Cycloaddition Reaction: Access to Spiro[chroman-3,2’-indene-1’,3’-dione] Scaffolds. ChemistrySelect 2017, 2 (35), 11380–11383.