SARS-CoV-2 Membrane Protein Structure & Function
Full-length membrane protein purification, liposome reconstitution, and structural characterization
This project develops membrane protein sample-preparation workflows for structural characterization of the full-length SARS-CoV-2 membrane (M) protein.
Key Contributions
- Expressed and purified full-length membrane protein
- Optimized detergent solubilization and liposome reconstitution
- Prepared samples for structural characterization using HS-AFM, TEM, and cryo-electron tomography